Do not take REYATAZ (atazanavir) if you are:
- Allergic to REYATAZ or to any of its ingredients
- Taking certain medicines with REYATAZ that may affect how REYATAZ works. REYATAZ may cause serious, life-threatening side effects or death if taken with the following medicines: alfuzosin (Uroxatral®), cisapride (Propulsid®), ergot medicines (refer to Patient Information for complete list of these medicines), indinavir (CRIXIVAN®), irinotecan (Camptosar®), lovastatin (Advicor®, Altoprev®, Mevacor®), midazolam (Versed®) when taken by mouth for sedation, nevirapine (Viramune®, Viramune XR®), pimozide (Orap®), rifampin (Rimactane®, Rifadin®, Rifater®, Rifamate®), sildenafil (Revatio®) when used for pulmonary arterial hypertension, simvastatin (Zocor®, Vytorin®, Simcor®), St. John's wort (Hypericum perforatum), triazolam (Halcion®)
Before taking REYATAZ, tell your healthcare provider if you:
- Have heart problems
- Have liver problems including hepatitis B or C infection
- Have phenylketonuria (PKU). REYATAZ oral powder contains phenylalanine as part of the artificial sweetener aspartame and can be harmful to people with PKU
- Are receiving dialysis treatment
- Have diabetes
- Have hemophilia
- Have any other medical conditions
- Are pregnant or plan to become pregnant. It is not known if REYATAZ will harm your unborn baby. When taking REYATAZ with other HIV medicines called nucleoside analogues, pregnant women have developed a serious condition called lactic acidosis
- Hormonal forms of birth control, such as injections, vaginal rings or implants, contraceptive patch, and some birth control pills, may not work when you are taking REYATAZ
- After your baby is born, tell your healthcare provider if your baby's skin or the white part of his/her eyes turns yellow
- Are breastfeeding or plan to breastfeed. Do not breastfeed if you have HIV. It is not known if REYATAZ passes into your breast milk
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. REYATAZ may affect the way other medicines work and other medicines may affect how REYATAZ works and may cause serious side effects. DO NOT take the following medicines while taking REYATAZ: boceprevir (VICTRELIS®), salmeterol (SEREVENT DISKUS®) and salmeterol with fluticasone (ADVAIR DISKUS®, ADVAIR HFA®), voriconazole (VFEND®).
Tell your healthcare provider right away if you take sildenafil (VIAGRA®), tadalafil (CIALIS®, ADCIRCA®) or vardenafil (LEVITRA®, STAXYN®). People who take REYATAZ with these medicines may increase their chance of having the following side effects: lightheadedness (especially when standing), fainting, changes in vision, an erection that lasts more than 4 hours.
The above list of medicines is not complete. Please refer to the Patient Information for a list of medicines that may require your therapy to be monitored more closely or may require a change in dose or dose schedule of REYATAZ (atazanavir) or the other medicine. Know the medicines you take. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine.
REYATAZ can cause serious side effects. Call your healthcare provider right away if you have any of the following:
- A change in the way your heart beats. You may feel dizzy or lightheaded as these could be symptoms of a heart problem
- Skin rash is common with REYATAZ and usually goes away within 2 weeks. Skin rash can sometimes be severe and may develop with other symptoms which can be serious. If you develop a severe rash with any of the following symptoms stop taking REYATAZ and call your healthcare provider right away: general feeling of discomfort, fever, muscle or joint aches, red or inflamed eyes, blisters, mouth sores, swelling of your face, painful, warm or red lump under the skin
- Yellowing of your skin or the white part of your eyes is common but may be a symptom of a serious problem. This may occur due to increases in bilirubin levels in the blood (bilirubin is made by the liver)
- Liver problems including hepatitis B or C may get worse when taking REYATAZ. Your healthcare provider will do blood tests before and during treatment with REYATAZ. Liver problem symptoms may include: your skin or the white part of your eyes turning yellow, dark tea colored urine, light colored stools, nausea, itching, or stomach area pain
- Kidney stones have happened in some people taking REYATAZ. Symptoms may include pain in your back or low stomach area, blood in your urine, pain when you urinate
- Gallbladder problems have happened in some people who take REYATAZ. Symptoms may include pain in the right or middle upper stomach area, fever, nausea and vomiting, and your skin or the white part of your eyes turning yellow
- Diabetes and high blood sugar have happened or worsened in some people who take protease inhibitor medicines like REYATAZ. Some people may need to start diabetes medicine or change their diabetes medicine
- Changes in your immune system (Immune Reconstitution Syndrome) can happen when you start taking HIV medicines. Tell your healthcare provider if you have any new symptoms after starting your HIV medicine
- Changes in body fat can happen in people taking HIV medicines. The cause and long-term health effects are not known.
- Hemophilia-Increased bleeding problems in people with hemophilia have happened when taking protease inhibitors like REYATAZ
The most common side effects of REYATAZ include: nausea, headache, stomach-area pain, vomiting, trouble sleeping, numbness, tingling, or burning of hands or feet, dizziness, muscle pain, diarrhea, depression, and fever
You should take REYATAZ capsules and oral powder once daily with food. Swallow the capsules whole; do not open the capsules. REYATAZ oral powder must be mixed with food or liquid and taken with ritonavir. Take REYATAZ exactly as your healthcare provider tells you to.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Click here for U.S. Full Prescribing Information, including Patient Information.